Kramm, C. M. et al. Thalamic high-grade gliomas in children: a distinct clinical subset? Neuro. Oncol. 13, 680–689 (2011). Kilian, M. et al. MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors. Cancer Cell 41, 235–251 (2023).

Vogl, C. (2016). Begone Satan! A soul-stirring account of diabolical possession in Iowa. (C. Kapsner, trans.). In C. Vogel, T. Geiger, & C. Kapsner (Eds.), Mary crushes the serpent and Begone Satan! Gilbert: Caritas Publishing. Jessa, S. et al. K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas. Nat. Genet. 54, 1865–1880 (2022). To maximize profit by growing user engagement and participation, social media companies have created sophisticated tools which filter information and place people in virtual echo chambers. These confirm or even radicalize the users’ world views. Currently, the algorithms underlying social media platforms’ business model amplify the angry and divisive voices which drive engagement, pushing users towards ever more extreme content. Maurer, L. M. et al. pH regulates genes for flagellar motility, catabolism, and oxidative stress in Escherichia coli K-12. J. Bacteriol. 187, 304–319 (2005). Tripp, J. H. et al. Misannotations of rRNA can now generate 90% false positive protein matches in metatranscriptomic studies. Nucleic Acids Res. 39, 8792–8802 (2011).

Team members

Grant, C. E. & Bailey, T. L. XSTREME: comprehensive motif analysis of biological sequence datasets. Preprint at bioRxiv https://doi.org/10.1101/2021.09.02.458722 (2021). While the building was under construction in late 1854, Bunsen suggested certain design principles to the university's mechanic, Peter Desaga, and asked him to construct a prototype. Similar principles had been used in an earlier burner design by Michael Faraday, and in a device patented in 1856 by gas engineer R. W. Elsner. The Bunsen/Desaga design generated a hot, sootless, non-luminous flame by mixing the gas with air in a controlled fashion before combustion. Desaga created adjustable slits for air at the bottom of the cylindrical burner, with the flame issuing at the top. When the building opened early in 1855, Desaga had made 50 burners for Bunsen's students. Two years later Bunsen published a description, and many of his colleagues soon adopted the design. Bunsen burners are now used in laboratories around the world. [6] Operation Bunsen burner flames depend on air flow in the throat holes (on the burner side, not the needle valve for gas flow): 1. air hole closed (safety flame used for lighting or default), 2. air hole slightly open, 3. air hole half-open, 4. air hole fully open (roaring blue flame). The QIAamp DNA Blood Mini kit (QIAGEN) was used to isolate genomic DNA from PBMCs of patients. A total of 100 µl DNA solution with a concentration of at least 20 ng µl −1 was submitted at room temperature for high-resolution HLA typing to DKMS, Germany. Briefly, at DKMS, long-range PCRs were performed, amplicons were fragmented and used for next-generation sequencing on an Illumina MiSeq device. The full HLA class I gene and exons 2–5 of HLA class II genes were analyzed using the NGSengine (GenDx) software. Depending on the resolution, typing results were delivered either as G-code or MAC/NMDP-code. MHC II immunohistochemistry

Broad Institute of Harvard and MIT and Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

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Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Schumacher, T. et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 512, 324–327 (2014). Hennon, G. M. M. et al. Diatom acclimation to elevated CO2 via cAMP signalling and coordinated gene expression. Nature Clim. Change 5, 761–765 (2015).Mullen, A. R. & DeBerardinis, R. J. Genetically-defined metabolic reprogramming in cancer. Trends Endocrinol. Metab. 23, 552–559 (2012). Wrong. In fact, over 30 years of design work and development has gone into the money belt products that we sell today. Our bags are designed for heavy and prolonged use in the most tough of environments and have been designed and tested in conjunction with some of the UK's busiest market traders!

Pelejero, C., Calvo, E. & Hoegh-Guldberg, O. Paleo-perspectives on ocean acidification. Trends Ecol. Evol. 25, 332–344 (2010). Chan, S. M. et al. Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nat. Med. 21, 178–184 (2015). Huson, D. H., Auch, A. F., Qi, J. & Schuster, S. C. MEGAN analysis of metagenomic data. Genome Res. 17, 377–386 (2007).Buescher, J. M., Moco, S., Sauer, U. & Zamboni, N. Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites. Anal. Chem. 82, 4403–4412 (2010). Teclu burner – The lower part of its tube is conical, with a round screw nut below its base. The gap, set by the distance between the nut and the end of the tube, regulates the influx of the air in a way similar to the open slots of the Bunsen burner. The Teclu burner provides better mixing of air and fuel and can achieve higher flame temperatures than the Bunsen burner. [9] [10] Bunse, L. et al. Proximity ligation assay evaluates IDH1R132H presentation in gliomas. J. Clin. Invest. 125, 593–606 (2015). Ray, R. M., Bavaria, M. & Johnson, L. R. Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ). Cell Signal. 27, 1850–1859 (2015).