Have you looked into Dr Eric Berg’s qualifications to give medical advice regarding cancer, let alone anything? Warburg, O. On respiratory impairment in cancer cells. Science 1956, 124, 269–370. [ Google Scholar] [ CrossRef] [ PubMed]

I took my GKI on Sunday after getting the Novamax Plus kit that measures both glucose and ketones, and was distressed to learn, despite three+ months of a low-carb diet (and losing 30 pounds,) that I was NOT ANYWHERE NEAR being in ketosis. Fan, J.; Lin, R.; Chen, D.; Xia, S.; Elf, S.E.; Liu, S.; Pan, Y.; Pan, Y.; Xu, H.; Qian, Z.; et al. Tetrameric Acetyl-CoA Acetyltransferase 1 is Important for tumor growth. Mol. Cell 2016, 64, 859–874. [ Google Scholar] [ CrossRef][ Green Version] Konishi, Y.; Kobayashi, S.; Shimizu, M. Tea Polyphenols inhibit the Transport of Dietary Phenolic Acids Mediated by the Monocarboxylic Acid Transporter (MCT) in Intestinal Caco-2 Cell Monolayers). J. Agric. Food Chem. 2003, 51, 7296–7302. [ Google Scholar] [ CrossRef] [ PubMed]Klement, R.J. Wilhelm Brünings’ forgotten contribution to the metabolic treatment of cancer utilizing hypoglycemia and very low carbohydrate (ketogenic) diet. J. Tradit. Complement. Med. 2019, 9, 192–200. [ Google Scholar] [ CrossRef] This first article in the starve cancer series is quite instructive. I had no idea that glucose levels could be brought down to the levels reported in the article. I have seen the tumor responses to fairly modest reduction in glucose in mice models; one can only guess what might happen if glucose levels were brought down to the extent imagined in the article. Aslam, M.N.; Bergin, I.; Naik, M.; Hampton, A.; Allen, R.; Kunkel, S.L.; Rush, H.; Varani, J. A multi-mineral natural product inhibits liver tumor formation in C57BL mice. Biol. Trace Elem. Res. 2012, 147, 267–274. [ Google Scholar] [ CrossRef][ Green Version] Blatt, J.; Stitely, S. Antineuroblastoma activity of desferoxamine in human cell lines. Cancer Res. 1987, 47, 1749–1750. [ Google Scholar] If using fasting as a strategy to lower glucose and glutamine, I was told that it takes 2 days to deplete glutamine levels and another 2 days to really start killing cancer cells. So, perhaps your fasts weren't long enough in duration. Prof Seyfried indicates that after 14 days he has not seen any cancer surviving in the patients he has been studying. I am gearing up to try a 4-7 day fast soon and hoping that will be enough.

He’s had no traditional treatment, but simply did lots of fasting and taking supplements and he’s been diagnosed as cancer free since last June. His metastasis are gone and only the old scars remain on his bone scans. Aside from having tried Zitiga for 2 months shortly after his diagnosis and having to stop because he was getting ulcers and other side-effects, he’s had no treatment like radiation, surgery or chemo. He still has his prostate intact, but he did get his testicles removed surgically shortly after stopping Zitiga because his doctor told him that this would lower his testosterone and maybe help him survive a little longer. He did not mind doing so because he thought he was going to die anyway. In general, HDACs, together with other compounds (NO donors), control the embryonic to adult transition for many protein isoforms. This depends, at the epigenetic level, on metabolites formed in glycolytic-ketogenic-ammonotellic fetal metabolism, or metabolites formed in adult oxidative metabolism. In mammals, a series of proteins of the “aquatic fetus” thus adapt to life in an environment with air and gravity [ 9].

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Wilson, B.R.; Bogdan, A.R.; Miyazawa, M.; Hashimoto, K. Siderophores in iron metabolism: From Mechanism to therapy. Trends Mol. Med. 2016, 22, 1077–1090. [ Google Scholar] [ CrossRef][ Green Version] Finally, if we limit the ketogenic supply to the SCOT ketolytic pathway it could be useful to preserve the signaling action over the HCA2 receptors, activated by agonists such as niacin. Quite a few men get Pca which is very weak, and easily defeated by say ADT + EBRT, and I've known men like that. But 2 years of ADT + 70Grey EBRT 1/2 way along was supposed to work, but after quitting ADT to see if it had worked, Psa went up from 0.08 to 8 in 6 months, so I have needed ADT ever since. Zhang, Y.-F.; Zhang, H.; He, L.; Liu, C.; Xu, Y.; Qian, P.-Y. Butenolide Inhibits Marine Fouling by altering the primary metabolism of three target organisms. ACS Chem. Biol. 2012, 7, 1049–1058. [ Google Scholar] [ CrossRef] [ PubMed]

We have seen quite a few iterations of the extreme starvation approach to cancer management in Medical Hypotheses and elsewhere. Those who have written about it have high technical knowledge and they appear to believe that there is justification in moving forward with animal testing. As I watched the Pca spread in scans get worse, the number of bone mets has increased, and I have many little ones not making PsMa hence Lu177 or Ac225 won'k, but Ra may work, but mean extension of lifetime of Ra223 is 4 months, but then men seeking Ra223 have tried all other things and have very high Psa, maybe 600, or 10 times what mine is. Abolhassani, R.; Berg, E.; Tenenbaum, G.; Israël, M. Inhibition of SCOT and Ketolysis decreases tumorGrowth and inflammation in the Lewis cancer model. JJ. Oncol. Clin. Res. 2022, 3, 1–12. [ Google Scholar] Yang, C.H.; Yen, T.L.; Hsu, C.Y.; Thomas, P.A.; Sheu, J.R.; Jayakumar, T. Multi-targeting Andrographolide, a novel NFkB Inhibitor, as a potential therapeutic agent for stroke. Int. J. Mol. Sci. 2017, 18, 1638. [ Google Scholar] [ CrossRef] [ PubMed]Apparently some (but not all) cancers can respond quite strongly to glucose lowering. There are a range of strategies that could help to achieve such glucose reduction. For example, even modest overnight fasting helps-- longer fasts could also be tried. For some, even longer fasts could be attempted, though professional medical advice would be necessary at some stage to maintain safety. Pal, D.; Saha, S. Hydroxamic acid–A novel molecule for anticancer therapy. J. Adv. Pharm. Technol. Res. 2012, 3, 92–98. [ Google Scholar] [ CrossRef] [ PubMed] Dimitrieva-Posocco, O.; Wong, A.C.; Lundgren, P.; Golos, A.M.; Descamps, H.C.; Cramer, Z.; Tian, Y.; Yueh, B.; Eskiocak, O.; Egervari, G.; et al. Beta-Hydroxybutyrate suppresses colorectal cancer. Nat. Commun. 2022, 605, 160–165. [ Google Scholar] [ CrossRef] [ PubMed] Lee, I.-K.; Han, M.-S.; Lee, M.-S.; Kinm, Y.-S.; Yun, B.-S. Styrylpyrones from the medicinal fungus Phellinusbaumii and their antioxidant properties. Bioorg. Med. Chem. Lett. 2010, 20, 5459–5461. [ Google Scholar] [ CrossRef] [ PubMed]

Warburg, O. On the origin of cancer cell. Science 1956, 123, 309–314. [ Google Scholar] [ CrossRef] [ PubMed] Israël, M. Genetic adaptation controlled by methylations and acetylation’s at the nuclear and cytosolic Levels: A hypothetical model. Neurochem. Res. 2003, 25, 631–635. [ Google Scholar] [ CrossRef] Considering the highly disappointing results from the TAILORX breast cancer study (specifically 85% of women with early breast cancer ( those with an identifiable genetic signature) received no benefited from traditional preventative treatments. How can metabolic therapies that have shown the success noted above now not be aggressively funded and researched? Glucose and ketone bodies are the two major sources of nutrients for cells. When food is scarce, a mobilization of nutritional reserves in several organs will liberate or synthesize these nutrients. Fasting and starvation elicit the release of catabolic hormones: glucagon from the endocrine pancreas, epinephrine and cortisol from adrenals. These hormones act on different organs: glucagon for the liver, muscle adipose tissues and liver for the others. Catabolic hormones trigger glycogenolysis in liver and muscle, making glucose available; these hormones will activate the synthesis of glucose through neoglucogenesis in the liver, while muscle proteolysis provides amino acids that support the process. On the other hand, tissues responding to anabolic hormones, insulin and insulin-like growth factor (IGF) will take up glucose. Glycolysis leads to pyruvate, recovering part of the energy of glucose. Then, mitochondrial oxidative metabolism takes over. This process is energetically more efficient than glycolysis, extracting energy through the citric acid Krebs cycle, which is coupled with the respiratory electron transport chain. The citric acid cycle begins with the conversion of pyruvate into acetyl-CoA by an enzyme pyruvate dehydrogenase (PDH), controlling the glycolytic entry in oxidative metabolism.Personally I have no problem with eating well and supplements and fasting but what works for the occasional person does not usually work for the masses. Otherwise we would all be doing well. I have tried everything you can think of in the alternative medical world. For my disease all it did was hurt my savings. I think diet is a no brainer and a healthy plant based diet is the way to go but all these other claims are either anecdotal or supported by very low level evidence with very small numbers of patients (therefore a low power study). Just because you can find an article on PubMed does not mean it is a good study. I think that is a major problem on this forum and others that people post links to “studies” but they really don’t know how to critically analyze them well. The conclusion is where everyone jumps to but in reality the methods is the most important part of any study. I’ve been a doc for 20 years and it took a long time for me to be confident in how I interpret a study. Bonuccelli, G.; Tsirigos, A.; Whitaker-Menez, D.; Pavlides, S.; Pestell, R.G.; Chiavarina, B.; Frank, P.G.; Flomenberg, N.; Howell, A.; Martinez-Outschoorn, U.E.; et al. Ketones and lactate “fuel” tumor growth and metastasis. Cell Cycle 2010, 9, 3506–3514. [ Google Scholar] [ PubMed] Gonçalves, J.M.; Barcellos Silva, C.M.; Rivero, E.R.C.; Cordeiro, M.M.R. Inhibition of Cancer stem cells promoted by Pimozide. Clin. Exp. Pharmacol. Physiol. 2019, 46, 116–125. [ Google Scholar] [ CrossRef][ Green Version] Kashan, A. Biological roles and therapeutic potential of hydroxyl-carboxilic acid receptors. Front. Endocrinol. 2011, 2, 1–12. [ Google Scholar]